- Extensive PK and PD sampling
- Continuous ECG
- EEG, qEEG, evoked potentials
- TQT, QTc, telemetry, holter and ambulatory monitoring
- PET, MRI, and CT scans; 64-slice CT, functional magnetic resonance imaging (fMRI), fiber tracking with the GE Signa HDx 3.0 Tesla MRI, and whole body imaging
- Lumbar puncture
- Continuous up to 24 hour CSF collection
- IV infusion, oral, transdermal patch and device delivery methods
- DEA licensed investigators experienced with managing opiate drugs in clinical trials
- Single and multiple ascending dose, fed and fasted, drug interaction, food effect, safety and efficacy
- Competitive or cohort enrollments – cohort sizes usually range between 4 to 12 subjects per cohort with an average inpatient stay of about 2-3 weeks
